{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:44:15Z","timestamp":1775504655072,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 104\u20102314\u2010B\u2010010\u2010011\u2010MY3"],"award-info":[{"award-number":["MOST 104\u20102314\u2010B\u2010010\u2010011\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Liver cirrhosis and portal hypertension are accompanied by hyperdynamic circulation, angiogenesis and portosystemic collaterals. Matrix metalloproteinases (MMPs) participate in fibrogenesis and angiogenesis, however, whether they can be targeted in cirrhosis treatment is unclear. Therefore, we performed three series of experiments to investigate this issue. Liver cirrhosis was induced by common bile duct ligation (BDL) in Sprague\u2010Dawley rats. Sham\u2010operated rats served as controls. Rats were randomly allocated to receive vehicle, minocycline (a nonselective MMP inhibitor) or SB\u20103CT (MMP\u20102 and \u22129 inhibitor) for 28\u00a0days in the first and second series, respectively. MMP\u20109\u00a0knockout mice were used in the third series. The results showed that minocycline ameliorated portal hypertension, hemodynamic abnormalities, reduced collateral shunting, mesenteric vascular density, plasma VEGF level and alleviated liver fibrosis. SB\u20103CT attenuated portal hypertension, hemodynamic derangements, reduced shunting, mesenteric vascular density, mesenteric VEGF protein expression, and liver fibrosis. Knockout BDL mice had significantly alleviated portal hypertension, liver fibrosis, liver \u03b1\u2010SMA and mesenteric eNOS protein expressions compared to wild\u2010type BDL mice. Liver SMAD2 phosphorylation was down\u2010regulated in all series with MMP inhibition or knock\u2010out. In conclusion, MMP\u20109 inhibition or deletion ameliorated the severity of cirrhosis, portal hypertension, and associated derangements. MMP\u20109\u00a0may be targeted in the treatment of liver cirrhosis.<\/jats:p>","DOI":"10.1111\/jcmm.16940","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:03:48Z","timestamp":1634515428000},"page":"10073-10087","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Matrix metalloproteinase\u20109 inhibition or deletion attenuates portal hypertension in rodents"],"prefix":"10.1111","volume":"25","author":[{"given":"Hui\u2010Chun","family":"Huang","sequence":"first","affiliation":[{"name":"Faculty of Medicine National Yang\u2010Ming University School of Medicine Taipei Taiwan"},{"name":"Faculty of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Division of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Division of General Medicine Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Ling","family":"Ho","sequence":"additional","affiliation":[{"name":"Faculty of Medicine National Yang\u2010Ming University School of Medicine Taipei Taiwan"},{"name":"Faculty of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Division of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Division of Gastroenterology and Hepatology Department of Medicine Lo\u2010Hsu Medical Foundation Lotung Poh\u2010Ai Hospital Yilan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Chih","family":"Chang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine National Yang\u2010Ming University School of Medicine Taipei Taiwan"},{"name":"Faculty of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Division of General Medicine Department of Medicine Taipei 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Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fa\u2010Yauh","family":"Lee","sequence":"additional","affiliation":[{"name":"Faculty of Medicine National Yang\u2010Ming University School of Medicine Taipei Taiwan"},{"name":"Faculty of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Division of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Hsiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine National Yang\u2010Ming University School of Medicine Taipei Taiwan"},{"name":"Faculty of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Division of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital Taipei 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