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Multiple hormones in the body regulate the development of breast cancer. Endocrine therapy is one of the primary treatments for hormone\u2010receptor\u2010positive breast cancer, but endocrine resistance is the primary clinical cause of treatment failure. Prolactin (PRL) is a protein hormone secreted by the pituitary gland, mainly promoting mammary gland growth, stimulating and maintaining lactation. Previous studies suggest that high PRL levels can increase the risk of invasive breast cancer in women. The expression levels of PRL and PRLR in breast cancer cells and breast cancer tissues are elevated in most ER\n                    <jats:sup>+<\/jats:sup>\n                    and ER\n                    <jats:sup>\u2212<\/jats:sup>\n                    tumours. PRL activates downstream signalling pathways and affects endocrine therapy resistance by combining with prolactin receptor (PRLR). In this review, we illustrated and summarized the correlations between endocrine therapy resistance in breast cancer and PRL, as well as the pathophysiological mechanisms and clinical practices. The study on PRL and its receptor would help explore reversing endocrine therapy\u2010resistance for breast cancer.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.16946","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T22:50:04Z","timestamp":1634683804000},"page":"10327-10348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Prolactin and endocrine therapy resistance in breast cancer: The next potential hope for breast cancer treatment"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8266-0771","authenticated-orcid":false,"given":"Yuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Breast Surgical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8209-042X","authenticated-orcid":false,"given":"Xiangyi","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Breast Surgical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3550-815X","authenticated-orcid":false,"given":"Lixue","family":"Xuan","sequence":"additional","affiliation":[{"name":"Department of Breast Surgical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongzhao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Breast Surgical Oncology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6020-9998","authenticated-orcid":false,"given":"Yen\u2010Hua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Cell Biology School of Medicine College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4499-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1982.243.2.E99"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"695","article-title":"Expression of prolactin and prolactin receptor in human breast carcinoma. 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