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Carfilzomib\u2010resistant (CR) MCL cell lines and primary samples were used for both\u00a0in vitro\u00a0and\u00a0in vivo\u00a0experiments to identify gene expression and explore their related signalling pathways. We first identified mucin 20 (<jats:italic>MUC20<\/jats:italic>) suppression in carfilzomib\u2010resistant MCL models. MUC20 overexpression sensitized cells to carfilzomib in vitro and in vivo. <jats:italic>MUC20<\/jats:italic> expression was inversely related to activation of c\u2010Met and the downstream p44\/42\u00a0MAPK pathway. c\u2010Met activation with hepatocyte growth factor (HGF) induced PI resistance, while c\u2010Met inhibition restored PI sensitivity. Carfilzomib resistance and depressed MUC20 expression were associated with enhanced proteasome activity and higher expression of proteassemblin (POMP), a chaperone for catalytically active proteasome assembly. c\u2010Met and POMP were associated through binding and induction of MAPK\u2010regulated ELK1 to the <jats:italic>POMP<\/jats:italic> promoter. Our data reveal that c\u2010Met signalling activation enhanced proteasome capacity as a mechanism of PI resistance, and <jats:italic>MUC20<\/jats:italic> expression may be a useful biomarker for PI therapy.<\/jats:p>","DOI":"10.1111\/jcmm.16953","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T18:19:28Z","timestamp":1634494768000},"page":"10164-10174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mucin 20 modulates proteasome capacity through c\u2010Met signalling to increase carfilzomib sensitivity in mantle cell lymphoma"],"prefix":"10.1111","volume":"25","author":[{"given":"Xiaobin","family":"Wang","sequence":"first","affiliation":[{"name":"The Departments of Hematology Shengjing Hospital China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fazal","family":"Shirazi","sequence":"additional","affiliation":[{"name":"The 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