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Glycolysis plays an essential role in T\u2010cell immune responses. Blocking glycolytic pathway in activated T cells represents a therapeutic strategy for restraint of immunologic process in autoimmune disorders. 2\u2010Deoxy\u2010D\u2010glucose (2\u2010DG) has been widely used to probe into glycolysis in immune cells. This study was aimed to explore the role of glycolysis inhibition by 2\u2010DG on regulating immune responses of OLP\u2010derived T cells. We observed that lactic dehydrogenase A (LDHA) expression was elevated in OLP lesions and local T cells. 2\u2010DG inhibited the expression of LDHA, p\u2010mTOR, Hif1\u03b1 and PLD2 in T cells; meanwhile, it decreased proliferation and increased apoptosis of T cells. T cells treated by 2\u2010DG showed lower LDHA expression and elevated apoptosis, resulting in a reduced apoptotic population of keratinocytes that were co\u2010cultured with them, which was related to the decreased levels of IFN\u2010\u03b3 in co\u2010culture system. Rapamycin enhanced the effects of 2\u2010DG on immune responses between T cells and keratinocytes. Thus, these findings indicated that OLP\u2010derived T cells might be highly dependent upon high glycolysis for proliferation, and 2\u2010DG treatment combined with rapamycin might be an option to alleviate T\u2010cell responses, contributing to reducing apoptosis of keratinocytes.<\/jats:p>","DOI":"10.1111\/jcmm.16964","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T16:58:01Z","timestamp":1634835481000},"page":"10257-10267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["2\u2010Deoxy\u2010D\u2010glucose impedes T cell\u2013induced apoptosis of keratinocytes in oral lichen planus"],"prefix":"10.1111","volume":"25","author":[{"given":"Fang","family":"Wang","sequence":"first","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (HubeiMOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology 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