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Exosomes can regulate the epithelial\u2010mesenchymal plasticity of tumour cells, remodel surrounding tumour microenvironment, and affect tumour cell proliferation, invasion and metastasis. However, the function and mechanism of exosomes in the intraperitoneal implantation of ovarian cancer remain unclear. In this study, exosomal annexin A2 (ANXA2) derived from ovarian cancer cells was co\u2010cultured with human peritoneal mesothelial (HMrSV5) cells; functional experiments were conducted to explore the effects of exosomal ANXA2 on the biological behaviour of HMrSV5 and the related mechanisms. This study showed that ANXA2 in ovarian cancer cells can be transferred to HMrSV5 cells through exosomes, exosomal ANXA2 can not only promote the migration, invasion and apoptosis of HMrSV5 cells, but also regulates morphological changes and fibrosis of HMrSV5 cells. Furthermore, ANXA2 promotes the mesothelial\u2010mesenchymal transition (MMT) and degradation of the extracellular matrix of HMrSV5 cells through PI3K\/AKT\/mTOR pathway, finally affects pre\u2010metastasis microenvironment of ovarian cancer, which provides a new theoretical basis for the mechanism of intraperitoneal implantation and metastasis of ovarian cancer.<\/jats:p>","DOI":"10.1111\/jcmm.16983","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T02:51:34Z","timestamp":1635821494000},"page":"10916-10929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial\u2010mesenchymal plasticity of human peritoneal mesothelial cells"],"prefix":"10.1111","volume":"25","author":[{"given":"Lingling","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Shengjing Hospital of China 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