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To better reveal the specific pathogenesis of PE, we characterized the proteome and acetyl proteome (acetylome) profile of placental tissue from PE and normal\u2010term pregnancy by label\u2010free quantification proteomics technology and PRM analysis. In this research, 373 differentially expressed proteins (DEPs) were identified by proteome analysis. Functional enrichment analysis revealed significant enrichment of DEPs related to angiogenesis and the immune system. COL12A1, C4BPA and F13A1\u00a0may be potential biomarkers for PE diagnosis and new therapeutic targets. Additionally, 700\u00a0Kac sites were identified on 585 differentially acetylated proteins (DAPs) by acetylome analyses. These DAPs may participate in the occurrence and development of PE by affecting the complement and coagulation cascades pathway, which may have important implications for better understand the pathogenesis of PE. In conclusion, this study systematically analysed the reveals critical features of placental proteins in pregnant women with PE, providing a resource for exploring the contribution of lysine acetylation modification to PE.<\/jats:p>","DOI":"10.1111\/jcmm.16997","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T07:47:53Z","timestamp":1635234473000},"page":"10614-10626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Systematic proteomics analysis of lysine acetylation reveals critical features of placental proteins in pregnant women with preeclampsia"],"prefix":"10.1111","volume":"25","author":[{"given":"Yu","family":"Shangguan","sequence":"first","affiliation":[{"name":"Clinical Medical Research Center Guangdong Provincial Engineering Research Center of Autoimmune Disease Precision Medicine Shenzhen Engineering Research Center of Autoimmune Disease The Second Clinical Medical 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