{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T03:27:47Z","timestamp":1752982067079,"version":"3.40.5"},"reference-count":50,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nuclear factor\u2010kappa B1 (NF\u2010\u03baB1), a pleiotropic transcription factor, functions as a critical contributor to tumorigenesis. Growing numbers of case\u2010control studies were carried out to analyse the potential contribution of <jats:italic>NF\u2010\u03baB1<\/jats:italic> gene variants to gastrointestinal cancer risk, yet remains conflicting conclusions. Therefore, we conducted this most up\u2010to\u2010date meta\u2010analysis to evaluate the relationship between <jats:italic>NF\u2010\u03baB1<\/jats:italic> gene insertion (I)\/deletion (D) polymorphism, namely \u221294ins\/delATTG or rs28362491, and the susceptibility to gastrointestinal cancers. We searched PubMed, EMBASE and MEDLINE databases updated in April 2021 for relevant studies. Meta\u2010analysis was carried out by software Stata11.0. The quantification of the relationship was determined by computing the combined odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). Sensitivity analysis, the funnel plot and Begg's rank correlation test were also applied. Our findings indicate that \u221294ins\/delATTG polymorphism could not significantly impact the susceptibility to gastrointestinal cancers. Under any five genetic models, \u221294ins\/delATTG polymorphism was not remarkedly linked to the risk of colorectal, gastric and oesophageal cancer, respectively. The significant role of \u221294ins\/delATTG was only observed in some certain subgroups. Findings here suggest that <jats:italic>NF\u2010\u03baB1<\/jats:italic>\u00a0gene \u221294ins\/delATTG polymorphism may not predispose to gastrointestinal cancer susceptibility.<\/jats:p>","DOI":"10.1111\/jcmm.17004","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T16:55:32Z","timestamp":1634835332000},"page":"10674-10683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Contributions of <i>NFKB1<\/i> \u201094insertion\/deletion ATTG polymorphism to the susceptibility of gastrointestinal cancers: A meta\u2010analysis"],"prefix":"10.1111","volume":"25","author":[{"given":"Hanqiang","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery The First People\u2019s Hospital of Zhaoqing Zhaoqing 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