{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:35:39Z","timestamp":1787060139090,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acute myeloid leukaemia (AML) is an aggressive form of blood cancer that carries a dismal prognosis. Several studies suggest that the poor outcome is due to a small fraction of leukaemic cells that elude treatment and survive in specialised, oxygen (O\n                    <jats:sub>2<\/jats:sub>\n                    )\u2010deprived niches of the bone marrow. Although several AML drug targets such as FLT3, IDH1\/2 and CD33 have been established in recent years, survival rates remain unsatisfactory, which indicates that other, yet unrecognized, mechanisms influence the ability of AML cells to escape cell death and to proliferate in hypoxic environments. Our data illustrates that Carbonic Anhydrases IX and XII (CA IX\/XII) are critical for leukaemic cell survival in the O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010deprived milieu. CA IX and XII function as transmembrane proteins that mediate intracellular pH under low O\n                    <jats:sub>2<\/jats:sub>\n                    conditions. Because maintaining a neutral pH represents a key survival mechanism for tumour cells in O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010deprived settings, we sought to elucidate the role of dual CA IX\/XII inhibition as a novel strategy to eliminate AML cells under hypoxic conditions. Our findings demonstrate that the dual CA IX\/XII inhibitor FC531\u00a0may prove to be of value as an adjunct to chemotherapy for the treatment of AML.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.17027","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T02:34:04Z","timestamp":1637202844000},"page":"11039-11052","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Pharmacological inhibition of Carbonic Anhydrase IX and XII to enhance targeting of acute myeloid leukaemia cells under hypoxic conditions"],"prefix":"10.1111","volume":"25","author":[{"given":"Fangli","family":"Chen","sequence":"first","affiliation":[{"name":"Melvin and Bren Simon Comprehensive Cancer Center Indiana University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Licarete","sequence":"additional","affiliation":[{"name":"Melvin and Bren Simon Comprehensive Cancer Center Indiana University Indianapolis Indiana USA"},{"name":"Department of Molecular Biology and Biotechnology Faculty of Biology and Geology Babes\u2010Bolyai University Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-9436","authenticated-orcid":false,"given":"Xue","family":"Wu","sequence":"additional","affiliation":[{"name":"Melvin and Bren Simon Comprehensive Cancer Center Indiana University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Petrusca","sequence":"additional","affiliation":[{"name":"Melvin and Bren Simon Comprehensive Cancer Center Indiana University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Callista","family":"Maguire","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austyn","family":"Colter","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George E.","family":"Sandusky","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Czader","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Indiana University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maegan L.","family":"Capitano","sequence":"additional","affiliation":[{"name":"Melvin and Bren Simon Comprehensive Cancer Center Indiana University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Ropa","sequence":"additional","affiliation":[{"name":"Melvin and Bren Simon Comprehensive Cancer Center Indiana University Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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