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Endothelial cells are the core regulator of CRS in many infectious diseases and may also play a key role after CAR\u2010T cell therapy. We provided a detailed clinical, laboratory description and endothelial cell activation biomarkers in patients with CRS. Endothelial cell activation was associated with occurrence, development and severity of CRS, manifested by decreased serum angiopoietin (Ang)\u20101\u00a0levels and increased levels of von Willebrand Factor (VWF), Ang\u20102, Ang\u20102:Ang\u20101, sE\u2010selectin, soluble intercellular adhesion molecule (sICAM\u20101) and soluble vascular cell adhesion molecule (sVCAM)\u20101. Besides, the endothelial activation was correlated with the hepatic, kidney and hematopoietic dysfunction in CRS patients. After infusion of CAR\u2010T cells, we detected changes of endothelial activation\u2010related biomarkers within 36\u00a0hours in patients who subsequently developed CRS, especially severe CRS. Using top tree models, we could predict which patients would develop CRS, especially severe CRS, or identify the severity of CRS by certain biomarkers of endothelial activation. These data provide a new idea and will help identify new targets for early intervention and prevention of CRS.<\/jats:p>","DOI":"10.1111\/jcmm.17029","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T01:44:00Z","timestamp":1635990240000},"page":"11063-11074","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Predictive role of endothelial cell activation in cytokine release syndrome after chimeric antigen receptor T cell therapy for acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8082-025X","authenticated-orcid":false,"given":"Fei","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Xi\u2019an Jiaotong University ShaanXi 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