{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:24:14Z","timestamp":1747185854220,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MH039","ZR2020QH051"],"award-info":[{"award-number":["ZR2020MH039","ZR2020QH051"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770382"],"award-info":[{"award-number":["81770382"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The administration of ACEI\/ARB (angiotensin\u2010converting enzyme inhibitors\/Angiotension II receptor blockers) in COVID\u201019 (coronavirus disease 2019) patients with hypertension exhibits a lower risk of mortality compared with ACEI\/ARB non\u2010users. In this context, an important question arises: is ACEI or ARB more suitable for the treatment of hypertensive COVID\u201019 patients? Taken into consideration the following four rationales, ARB may offer a more significant benefit than ACEI for the short\u2010term treatment of hypertensive COVID\u201019 patients: 1. ACEI has no inhibition on non\u2010ACE\u2010mediated Ang II production under infection conditions, whereas ARB can function properly regardless of how Ang II is produced; 2. ACEI\u2010induced bradykinin accumulation may instigate severe ARDS while ARB has no effects on kinin metabolism; 3. ARB alleviates viscous sputa production and inflammatory reaction significantly in contrast to ACEI; 4. ARB may attenuate the lung fibrosis induced by mechanical ventilation in severe patients and improve their prognosis significantly compared with ACEI. To examine the advantages of ARB over ACEI on hypertensive COVID\u201019 patients, retrospective case\u2010control studies comparing the clinical outcomes for COVID\u201019 patients receiving ARB or ACEI treatment is strikingly needed in order to provide guidance for the clinical application.<\/jats:p>","DOI":"10.1111\/jcmm.17051","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T04:41:04Z","timestamp":1636692064000},"page":"11031-11034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["ARB might be superior to ACEI for treatment of hypertensive COVID\u201019 patients"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5296-2293","authenticated-orcid":false,"given":"Hong\u2010Jin","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cardiology Shandong Provincial Hospital affiliated to Shandong First Medical University Ji'nan 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