{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:47:39Z","timestamp":1790747259676,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Majority of current treatment strategies against erectile dysfunction (ED) has been consisted of only a supportive care to sustain enough erection during a sexual intercourse. In this study, we investigated whether the cultured conditioned medium of human exfoliated deciduous dental pulp stem cells (SHED\u2010CM) had an ability to treat ED through fundamentally repairing the pathological damage of vascular endothelial cells of the corpus cavernosum. An open\u2010label pilot study was performed from April 2016 to October 2020. SHED\u2010CM was injected directly into the corpus cavernosum of penis of 38 ED patients who visited our clinic and fulfilled the inclusion criteria. Efficacy was assessed using the simplified International Index of Erectile Function (IIEF\u20105) questionnaire. The average age and initial IIEF\u20105 score of the patients enrolled in this study was 56 (31\u201379) years old and 13.1 (5\u201320) points, respectively. Medical history revealed 7 patients with diabetes, 7 patients with hypertension and 1 patient with priapism undergone shunt operation. Of these, 37 patients (97.4%) showed an improvement in IIEF\u20105 of an average of 19.3 (7\u201325) points or 64.4 (10\u2013300) % increase after three injections of SHED\u2010CM. Eighteen patients (47.4%) achieved more than 21 points (no ED) in IIEF\u20105. No adverse events were encountered. This is the first clinical report of ED treatment in the literatures evaluating the efficacy of SHED\u2010CM. Treatment with SHED\u2010CM is expected to repair vascular damages of the corpus cavernosum, which are the main cause of ED, and to be widely spread as a fundamental clinical application for ED.<\/jats:p>","DOI":"10.1111\/jcmm.17072","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T11:33:05Z","timestamp":1638271985000},"page":"195-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Efficacy of a cultured conditioned medium of exfoliated deciduous dental pulp stem cells in erectile dysfunction patients"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5876-663X","authenticated-orcid":false,"given":"Shoji","family":"Koga","sequence":"first","affiliation":[{"name":"Ginza Solaria Clinic Panagy Co., Ltd. Tokyo Japan"},{"name":"Department of Urology Edogawa Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Horiguchi","sequence":"additional","affiliation":[{"name":"Department of Urology Edogawa Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2015.10.011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)02102-7"},{"key":"e_1_2_9_4_1","first-page":"16003","article-title":"Large\u2010scale questionnaire survey of erectile dysfunction drugs in Japanese men","volume":"2","author":"Nagao K","year":"2008","journal-title":"Reprod Med Biol"},{"key":"e_1_2_9_5_1","first-page":"105","article-title":"Erectile dysfunction","volume":"7","author":"Yafi FA","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"e_1_2_9_6_1","first-page":"150","article-title":"Treatment of diabetic impotence with umbilical cord blood stem cell intracavernosal transplant: preliminary report of 7 cases","volume":"8","author":"Bahk JY","year":"2010","journal-title":"Exp Clin Transplant"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208100806"},{"key":"e_1_2_9_8_1","first-page":"80","article-title":"Human dental pulp\u2010derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro\u2010regenerative mechanisms","volume":"122","author":"Sakai S","year":"2012","journal-title":"J Clin Invest"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501457"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.01.024"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0937635100"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3900472"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14949"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-020-00149-0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.249243"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2019.05.006"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.05.014"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16295"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2011.0385"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4088-14.2015"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.140707"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicines7030014"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9112385"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.17072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.17072","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.17072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T06:32:52Z","timestamp":1738391572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.17072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,29]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/jcmm.17072"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.17072","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,29]]},"assertion":[{"value":"2021-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}