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Recent researches have documented that the traditional Chinese medicine, Sparstolonin B (Ssn B), exerted anti\u2010inflammatory effects in various diseases, but not yet in OA. On the basis of this evidence, our works purposed to evaluate the effect of Ssn B on free fatty acid (FFA) palmitate (PA)\u2010stimulated human osteoarthritic chondrocytes and obesity\u2010associated mouse OA model. We found that Ssn B suppressed PA\u2010triggered inflammatory response and extracellular matrix catabolism in a concentration\u2010dependent approach. <jats:italic>In vivo<\/jats:italic>, Ssn B treatment inhibited cartilage degeneration and subchondral bone calcification caused by joint mechanical imbalance and alleviated metabolic inflammation in obesity. Mechanistically, co\u2010immunoprecipitine and molecular docking analysis showed that the formation of toll\u00adlike receptor 4 (TLR4)\/myeloid differentiation protein\u20102 (MD\u20102) complex caused by PA was blocked by Ssn B. Subsequently, it leads to inactivation of PA\u2010caused myeloid differentiation factor 88 (MyD88)\u2010dependent nuclear factor\u2010kappaB (NF\u2010\u03baB) cascade. Together, these findings demonstrated that Ssn B is a potential treatment agent for joint degenerative diseases in obese individuals.<\/jats:p>","DOI":"10.1111\/jcmm.17099","type":"journal-article","created":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T07:06:18Z","timestamp":1640415978000},"page":"725-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sparstolonin B suppresses free fatty acid palmitate\u2010induced chondrocyte inflammation and mitigates post\u2010traumatic arthritis in obese mice"],"prefix":"10.1111","volume":"26","author":[{"given":"Haiwei","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenglong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department 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