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Obesity and nonalcoholic fatty liver disease (NAFLD) also significantly enhance the risk of liver cancer. Despite recent improvements in therapeutic approaches, patients diagnosed in advanced stages show poor prognosis. Accumulating evidence provides support for the regulatory role of non\u2010coding RNAs (ncRNAs) in cancer. There are a variety of reports indicating the regulatory role of microRNAs (miRNAs) in different stages of HCC. Long non\u2010coding RNAs (LncRNAs) exert their effects by sponging miRNAs and controlling the expression of miRNA\u2010targeted genes. Circular RNAs (circRNAs) perform their biological functions by acting as transcriptional regulators, miRNA sponges and protein templates. Diverse studies have illustrated that dysregulation of competing endogenous RNA networks (ceRNETs) is remarkably correlated with HCC\u2010causing diseases such as chronic viral infections, nonalcoholic steatohepatitis and liver fibrosis\/cirrhosis. The aim of the current article was to provide an overview of the role and molecular mechanisms underlying the function of ceRNETs that modulate the characteristics of HCC such as uncontrolled cell proliferation, resistance to cell death, metabolic reprogramming, immune escape, angiogenesis and metastasis. The current knowledge highlights the potential of these regulatory RNA molecules as novel diagnostic biomarkers and therapeutic targets in HCC.<\/jats:p>","DOI":"10.1111\/jcmm.17126","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T04:54:57Z","timestamp":1639544097000},"page":"287-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Non\u2010coding RNA\u2010associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma"],"prefix":"10.1111","volume":"26","author":[{"given":"Sattar","family":"Khashkhashi Moghadam","sequence":"first","affiliation":[{"name":"Research and Development Center of Biotechnology Tarbiat Modares University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Bakhshinejad","sequence":"additional","affiliation":[{"name":"Department of Molecular 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