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Despite a multimodal treatment response, survival for GBM patients remains between 12 and 15\u00a0months. Anti\u2010ELTD1 antibody therapy is effective in decreasing tumour volumes and increasing animal survival in an orthotopic GBM xenograft. OKN\u2010007 is a promising chemotherapeutic agent that is effective in various GBM animal models and is currently in two clinical trials. In this study, we sought to compare anti\u2010ELTD1 and OKN\u2010007 therapies, as single agents and combined, against bevacizumab, a commonly used therapeutic agent against GBM, in a human G55 xenograft mouse model. MRI was used to monitor tumour growth, and immunohistochemistry (IHC) was used to assess tumour markers for angiogenesis, cell migration and proliferation in the various treatment groups. OKN and anti\u2010ELTD1 treatments significantly increased animal survival, reduced tumour volumes and normalized the vasculature. Additionally, anti\u2010ELTD1 was also shown to significantly affect other pro\u2010angiogenic factors such as Notch1 and VEGFR2. Unlike bevacizumab, anti\u2010ELTD1 and OKN treatments did not induce a pro\u2010migratory phenotype within the tumours. Anti\u2010ELTD1 treatment was shown to be as effective as OKN therapy. Both OKN and anti\u2010ELTD1 therapies show promise as potential single\u2010agent multi\u2010focal therapies for GBM patients.<\/jats:p>","DOI":"10.1111\/jcmm.17133","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T05:05:33Z","timestamp":1639544733000},"page":"570-582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A tale of two multi\u2010focal therapies for glioblastoma: An antibody targeting ELTD1 and nitrone\u2010based OKN\u2010007"],"prefix":"10.1111","volume":"26","author":[{"given":"Michelle","family":"Zalles","sequence":"first","affiliation":[{"name":"Advanced Magnetic Resonance Center Oklahoma Medical Research Foundation Oklahoma City Oklahoma USA"},{"name":"Oklahoma Center for Neuroscience University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 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