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Intracellular CIRP could also be released into extracellular space and once released, extracellular CIRP (eCIRP) acts as a damage\u2010associated molecular pattern (DAMP) to induce and amplify inflammation. Recent studies have found that eCIRP could promote acute lung injury (ALI) via activation of macrophages, neutrophils, pneumocytes and lung vascular endothelial cells in context of sepsis, haemorrhagic shock, intestinal ischemia\/reperfusion injury and severe acute pancreatitis. In addition, CIRP is also highly expressed in the bronchial epithelial cells and its expression is upregulated in the bronchial epithelial cells of patients with chronic obstructive pulmonary diseases (COPD) and rat models with chronic bronchitis. CIRP is a key contributing factor in the cold\u2010induced exacerbation of COPD by promoting the expression of inflammatory genes and hypersecretion of airway mucus in the bronchial epithelial cells. Besides, CIRP is also involved in regulating pulmonary fibrosis, as eCIRP could directly activate and induce an inflammatory phenotype in pulmonary fibroblast. This review summarizes the findings of CIRP investigation in respiratory diseases and the underlying molecular mechanisms.<\/jats:p>","DOI":"10.1111\/jcmm.17142","type":"journal-article","created":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T06:53:28Z","timestamp":1640415208000},"page":"957-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The role of Cold\u2010Inducible RNA\u2010binding protein in respiratory diseases"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0347-4514","authenticated-orcid":false,"given":"Peng","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan Hubei China"},{"name":"Cardiovascular Research Institute of Wuhan University Wuhan Hubei China"},{"name":"Hubei Key Laboratory of Cardiology Wuhan Hubei 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