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In the bone environment, FGF\u20108 produced or received by chondrocyte precursor cells binds to fibroblast growth factor receptor (FGFR), causing different levels of activation of downstream signalling pathways, such as phospholipase C gamma (PLC\u03b3)\/Ca<jats:sup>2+<\/jats:sup>, RAS\/mitogen\u2010activated protein kinase\u2010extracellular regulated protein kinases (RAS\/MAPK\u2010MEK\u2010ERK), and Wnt\u2010\u03b2\u2010catenin\u2010Axin2 signalling, and ultimately controlling chondrocyte proliferation, differentiation, cell survival and migration. However, the molecular mechanism of FGF\u20108 in normal or pathological cartilage remains unclear, and thus, FGF\u20108 represents a novel exploratory target for studies of chondrocyte development and cartilage disease progression. In this review, studies assessing the relationship between FGF\u20108 and chondrocytes that have been published in the past 5\u00a0years are systematically summarized to determine the probable mechanism and physiological effect of FGF\u20108 on chondrocytes. 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