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We have previously reported that astilbin decreases proliferation and improves differentiation of HaCaT keratinocytes in a psoriatic model. The present study was designed to evaluate the potential therapeutic effects of topical administration of astilbin on an imiquimod (IMQ)\u2010induced psoriasis\u2010like murine model and to reveal their underlying mechanisms. Topical administration of astilbin at a lower dose alleviated IMQ\u2010induced psoriasis\u2010like skin lesions by inducing the differentiation of epidermal keratinocytes in mice, and the therapeutic effect was even better than that of calcipotriol. Moreover, the inflammatory skin disorder was relieved by astilbin treatment characterized by a reduction in both IL\u201017\u2010producing T cell accumulation and psoriasis\u2010specific cytokine expression in skin lesions. Furthermore, we found that astilbin inhibited R837\u2010induced maturation and activation of bone marrow\u2010derived dendritic cells and decreased the expression of pro\u2010inflammatory cytokines by downregulating myeloid differentiation factor 88. Our findings provide the convincing evidence that lower doses of astilbin might attenuate psoriasis by interfering with the abnormal activation and differentiation of keratinocytes and accumulation of IL\u201017\u2010producing T cells in skin lesions. Our results strongly support the pre\u2010clinical application of astilbin for psoriasis treatment.<\/jats:p>","DOI":"10.1111\/jcmm.17184","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T01:09:21Z","timestamp":1642036161000},"page":"1281-1292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Topical astilbin ameliorates imiquimod\u2010induced psoriasis\u2010like skin lesions in SKH\u20101 mice via suppression dendritic cell\u2010Th17 inflammation axis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7703-5872","authenticated-orcid":false,"given":"Qingqing","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Venereology The Second Hospital Cheeloo College of Medicine Shandong University Jinan 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Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangshang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology The Second Hospital Cheeloo College of Medicine Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Sun","sequence":"additional","affiliation":[{"name":"The Second Hospital Cheeloo College of Medicine Shandong University Jinan China"},{"name":"Advanced Medical Research Institute Cheeloo College of Medicine Shandong University Jinan 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