{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:10:33Z","timestamp":1787015433428,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2016_A188"],"award-info":[{"award-number":["2016_A188"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ageing is often accompanied by an increase in bone marrow fat together with reduced bone volume and diseases of the bone such as osteoporosis. As mesenchymal stem cells (MSCs) are capable of forming bone, cartilage and fat tissue, studying these cells is of great importance to understand the underlying mechanisms behind age\u2010related bone diseases. However, inter\u2010donor variation has been found when handling MSCs. Therefore, the aim of this study was to investigate the effects of donor age and sex by comparing in vitro characteristics of human bone marrow\u2010derived MSCs (hBMSCs) from a large donor cohort (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0175). For this, hBMSCs were analysed for CFU\u2010F capacity, proliferation, differentiation capacity and surface antigen expression under standardized culture conditions. The results demonstrated a significantly reduced CFU\u2010F number for hBMSCs of female compared to male donors. Furthermore, there was a significant decrease in the proliferation rate, adipogenic differentiation potential and cell surface expression of SSEA\u20104, CD146 and CD274 of hBMSCs with an increase in donor age. Interestingly, all these findings were exclusive to hBMSCs from female donors. Further research should focus on postmenopausal\u2010related effects on hBMSCs, as the results imply a functional loss and immunophenotypic change of hBMSCs particularly in aged women.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.17201","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:39:44Z","timestamp":1643330384000},"page":"1594-1605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Influence of age on stem cells depends on the sex of the bone marrow donor"],"prefix":"10.1111","volume":"26","author":[{"given":"Michael","family":"Selle","sequence":"first","affiliation":[{"name":"Trauma Department Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna Dorothea","family":"Koch","sequence":"additional","affiliation":[{"name":"Trauma Department Hannover Medical School  Hannover 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