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Thus, mammalian Ste20\u2010like kinase 1\/2 (MST1\/2) as the core serine\u2010threonine kinases in the Hippo signalling pathway has been investigated for its role in immunological disease. However, little information of MST1\/2 function in bone marrow suppression induced by ionizing radiation was fully investigated. Here, we reported that MST1\/2 inhibitor XMU\u2010MP\u20101 could rescue the impaired haematopoietic stem cells (HSCs) and progenitor cells (HPCs) function under oxidative stress condition. Also, XMU\u2010MP\u20101 pretreatment markedly alleviated the small intestinal system injury caused by the total body irradiation 9\u00a0Gy and extended the average survival days of the mice exposed to the lethal dose radiation. Therefore, irradiation exposure causes the serious pathological changes of haematopoietic and intestinal system, and XMU\u2010MP\u20101 could prevent the ROS production, the haematopoietic cells impairment and the intestinal injury. These detrimental effects may be associated with regulating NOX\/ROS\/P38MARK pathway by MST1\/2.<\/jats:p>","DOI":"10.1111\/jcmm.17203","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T05:39:26Z","timestamp":1643348366000},"page":"1621-1628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["MST1\/2 inhibitor XMU\u2010MP\u20101 alleviates the injury induced by ionizing radiation in haematopoietic and intestinal system"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7929-5988","authenticated-orcid":false,"given":"Xiaoliang","family":"Zhou","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Institute of Radiation Medicine Chinese Academy of Medical Science &amp; Peking Union Medical College  Tianjin 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