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Differentiated embryo\u2010chondrocyte expressed gene 1 (DEC1) is dysregulated in some cancers and may regulate cell proliferation in specific contexts. Of note, DEC1 is emerging as one of the important factors regulating cellular responses in microenvironment. However, the triggers and precise regulation mechanism for DEC1 during inflammatory carcinoma transformation of GC are unclear. In this study, we identified DEC1 was upregulated in both <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic>\u2010infected gastric tissues and GC cells. DEC1 expression was positively associated with <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> infection status and GC progression. DEC1\u2010positive expression indicated a poorer prognosis in <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic>\u2010positive GC. DEC1 was required for <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic>\u2010induced GC cells proliferation. Mechanistically, <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> infection significantly activated Akt\/NF\u2010\u03baB signal pathway and this induction depend on DEC1 expression level in GC cells. Importantly, their interaction pathway was further verified by <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic>\u2010positive gastritis mice model. Taken together, our findings identified a novel function of DEC1 in GC. <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic> infection induce DEC1 expression, and which leading to the progression of GC through activating Akt\/ NF\u2010\u03baB signalling pathway. Blocking DEC1\/Akt\/NF\u2010\u03baB, therefore, presents a promising novel therapeutic strategy for <jats:italic>H<\/jats:italic>. <jats:italic>pylori<\/jats:italic>\u2010positive GC.<\/jats:p>","DOI":"10.1111\/jcmm.17219","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T07:17:55Z","timestamp":1644045475000},"page":"1943-1954","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["DEC1 promotes progression of <i>Helicobacter pylori<\/i>\u2010positive gastric cancer by regulating Akt\/NF\u2010\u03baB pathway"],"prefix":"10.1111","volume":"26","author":[{"given":"Yanfei","family":"Jia","sequence":"first","affiliation":[{"name":"Research Center of Basic Medicine Jinan Central Hospital Shandong First Medical University  Jinan China"},{"name":"Research Center of Basic Medicine Jinan Central Hospital Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Center of Basic Medicine Jinan Central Hospital Cheeloo College of Medicine Shandong University  Jinan China"},{"name":"Department of Clinical Laboratory Qilu Hospital Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Jinan Central Hospital Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Jinan Central Hospital Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-8354","authenticated-orcid":false,"given":"Xiaoli","family":"Ma","sequence":"additional","affiliation":[{"name":"Research Center of Basic Medicine Jinan Central Hospital Shandong First Medical University  Jinan China"},{"name":"Research Center of Basic Medicine Jinan Central Hospital Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duanrui","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Center of Basic Medicine Jinan Central Hospital Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Han","sequence":"additional","affiliation":[{"name":"Medical Research &amp; Laboratory Diagnostic Center Jinan Central Hospital Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center of Basic Medicine Jinan Central Hospital Shandong First Medical University  Jinan China"},{"name":"Research Center of Basic Medicine Jinan Central Hospital Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Qiang","family":"Ling","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Institute The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-185X","authenticated-orcid":false,"given":"Yunshan","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center of Basic Medicine Jinan Central Hospital Shandong First Medical University  Jinan China"},{"name":"Research Center of Basic Medicine Jinan Central Hospital Cheeloo College of Medicine Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Schistosomes liver flukes and Helicobacter pylori.IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. 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