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NAD\n                    <jats:sup>+<\/jats:sup>\n                    is a pivotal determinant of cellular energy metabolism involved in the progression of AKI; however, its mechanism in kidney injury remains poorly understood. Sirtuin 1 (SIRT1) is an NAD\n                    <jats:sup>+<\/jats:sup>\n                    \u2010dependent deacetylase associated with renal protection and acute stress resistance. In this study, we have investigated the role of NAD\n                    <jats:sup>+<\/jats:sup>\n                    in AKI and the potential mechanism(s) involved in its renoprotective effect. NAD\n                    <jats:sup>+<\/jats:sup>\n                    was notably decreased and negatively correlated with kidney dysfunction in AKI, restoring NAD\n                    <jats:sup>+<\/jats:sup>\n                    with NMN significantly ameliorates LPS\u2010induced oxidative stress and apoptosis and attenuates renal damage. We also found that the protection of NAD\n                    <jats:sup>+<\/jats:sup>\n                    is associated with SIRT1 expressions and performs in a SIRT1\u2010dependent manner. Inhibition of SIRT1 blunted the protective effect of NAD\n                    <jats:sup>+<\/jats:sup>\n                    and up\u2010regulated the activity of glycogen synthase kinase\u20103\u03b2 (GSK\u20103\u03b2) that was concomitant with mitigated Nrf2 nuclear accumulation, thereby exacerbates AKI. These findings suggest that NAD\n                    <jats:sup>+<\/jats:sup>\n                    \/SIRT1\/GSK\u20103\u03b2\/Nrf2 axis is an important mechanism that can protect against AKI which might be a potential therapeutic target for the treatment of AKI.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.17222","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T05:02:46Z","timestamp":1644382966000},"page":"1979-1993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["NAD\n                    <sup>+<\/sup>\n                    ameliorates endotoxin\u2010induced acute kidney injury in a sirtuin1\u2013dependent manner via GSK\u20103\u03b2\/Nrf2 signalling pathway"],"prefix":"10.1111","volume":"26","author":[{"given":"Simeng","family":"He","sequence":"first","affiliation":[{"name":"School of Medicine Nankai University  Tianjin 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