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We investigated the mechanism and influence of Docetaxel and Telmisartan (as an analogous to ADH\u20101, which is a well\u2010known N\u2010cadherin antagonist) on cancer cells. The effect of ADH\u20101 and Telmisartan on cell attachment in PC3, DU145, MDA\u2010MB\u2010468 cell lines using recombinant human N\u2010cadherin was studied. Cell viability assay was performed to examine the anti\u2010proliferative effects of Telmisartan, ADH\u20101 and Docetaxel. Migration was examined via wound healing assay, and apoptosis was determined by flow cytometry. The expression of AKT\u20101 as a downstream gene of N\u2010cadherin signalling pathway was assayed by real\u2010time PCR. Treatment of PC3, MDA\u2010MB\u2010468 and DU145 cells with Telmisartan (0.1\u00a0\u00b5M) and ADH\u20101 (40\u00a0\u00b5M) resulted in 50%, 58% and approximately 20% reduction in cell attachment to N\u2010cadherin coated plate respectively. It shows reduction of cell attachment in PC3 and MDA\u2010MB\u2010468 cell lines appeared to be more sensitive than that of DU145 cells to the Telmisartan and ADH\u20101 treatments. Telmisartan (0.1\u00a0\u00b5M) and Docetaxel (0.01\u00a0nM) significantly reduced cell migration in PC3 and MDA\u2010MB\u2010468 cell lines compared with the control group. Using Real\u2010time PCR, we found that Telmisartan, Docetaxel and ADH\u20101 had significant influence on the AKT\u20101 mRNA level. The results of the current study for the first time suggest that, Telmisartan, exerts anti\u2010proliferation and anti\u2010migration effects by targeting antagonistically N\u2010cadherin. Also, these data suggest that Telmisartan as a less expensive alternative to ADH\u20101 could potentiate Docetaxel anticancer effects.<\/jats:p>","DOI":"10.1111\/jcmm.17259","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T02:33:45Z","timestamp":1646015625000},"page":"2392-2403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Telmisartan anti\u2010cancer activities mechanism through targeting N\u2010cadherin by mimicking ADH\u20101 function"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8818-7177","authenticated-orcid":false,"given":"Marjan","family":"Khorsand","sequence":"first","affiliation":[{"name":"Department of Biochemistry School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Khajeh","sequence":"additional","affiliation":[{"name":"Bone 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