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Following establishment of intestinal IRI models by superior mesenteric artery occlusion in Wistar rats, the expression and distribution patterns of TERT were detected. The IRI rats were subsequently treated with low or high doses of dexmedetomidine, followed by detection of ROS, MDA and GSH levels. Calcein cobalt and rhodamine 123\u00a0staining were also carried out to detect mitochondrial permeability transition pore (MPTP) and the mitochondrial membrane potential (MMP), respectively. Moreover, oxidative injury of mtDNA was determined, in addition to analyses of EGC viability and apoptosis. Intestinal tissues and mitochondria of EGCs were badly damaged in the intestinal IRI group. In addition, there was a reduction in mitochondrial localization of TERT, oxidative stress, whilst apoptosis of EGCs was increased and proliferation was decreased. On the other hand, administration of dexmedetomidine was associated with promotion of mitochondrial localization of TERT, whilst oxidative stress, MPTP and mtDNA in EGCs, and EGC apoptosis were all inhibited, and the MMP and EGC viability were both increased. A positive correlation was observed between different doses of dexmedetomidine and protective effects. Collectively, our findings highlighted the antioxidative effects of dexmedetomidine on EGCs following intestinal IRI, as dexmedetomidine alleviated mitochondrial damage by enhancing the mitochondrial localization of TERT.<\/jats:p>","DOI":"10.1111\/jcmm.17261","type":"journal-article","created":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T05:56:17Z","timestamp":1648878977000},"page":"2594-2606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dexmedetomidine reduces enteric glial cell injury induced by intestinal ischaemia\u2010reperfusion injury through mitochondrial localization of TERT"],"prefix":"10.1111","volume":"26","author":[{"given":"Qian","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First Affiliated Hospital of Nanchang University  Nanchang 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