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Pyroptosis, a novel form of programmed cell death, is reported to take part in the pathogenesis and progression of acute or chronic liver diseases and liver fibrosis. Caspase\u20101 dependent canonical pathway and caspase\u20104\/\u20105\/\u201011\u00a0mediated noncanonical pathway are the two signalling pathways to induce pyroptosis. The activation of inflammasomes under the stimulation of pathogenic microorganisms and danger signals can initiate the pyroptotic pathway and release large amounts of proinflammatory and profibrotic cytokines. This article comprehensively summarizes recent researches focused on the mechanism of pyroptosis and its role in major hepatic cells, which can provide potential therapeutic strategies for liver fibrosis.<\/jats:p>","DOI":"10.1111\/jcmm.17277","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T07:02:26Z","timestamp":1649833346000},"page":"2757-2765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Multi\u2010faceted role of pyroptosis mediated by inflammasome in liver fibrosis"],"prefix":"10.1111","volume":"26","author":[{"given":"Hui","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Infectious Disease The Third Xiangya hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The Third Xiangya 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