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Although autologous fat transplantation has many advantages, the low retention rate of adipose tissue limits its clinical application. Here, we identified a secretory glycoprotein, leucine\u2010rich\u2010alpha\u20102\u2010glycoprotein 1 (LRG\u20101), that could promote fat graft survival through RAB31\u2010mediated inhibition of hypoxia\u2010induced apoptosis. We showed that LRG\u20101 injection significantly increased the maintenance of fat volume and weight compared with the control. In addition, higher fat integrity, more viable adipocytes and fewer apoptotic cells were observed in the LRG\u20101\u2010treated groups. Furthermore, we discovered that LRG\u20101 could reduce the ADSC apoptosis induced by hypoxic conditions. The mechanism underlying the LRG\u20101\u2010mediated suppression of the ADSC apoptosis induced by hypoxia was mediated by the upregulation of RAB31 expression. Using LRG\u20101 for fat grafts may prove to be clinically successful for increasing the retention rate of transplanted fat.<\/jats:p>","DOI":"10.1111\/jcmm.17280","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T03:05:05Z","timestamp":1648091105000},"page":"3153-3168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["LRG\u20101 promotes fat graft survival through the RAB31\u2010mediated inhibition of hypoxia\u2010induced apoptosis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6861-7870","authenticated-orcid":false,"given":"Chia\u2010kang","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Plastic &amp; Reconstructive Surgery School of Medicine Shanghai Ninth People\u2019s Hospital Shanghai Jiao Tong University  Shanghai 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