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Here, we report that overexpression of PD\u2010L1 (B7\u00a0homolog1) in the testis causes sperm developmental disorders and infertility in male mice, with severe malformation and sloughing during spermatid development, characterized by disorganized and collapsed seminiferous epithelium structure. PD\u2010L1 needs to be simultaneously expressed on Sertoli cells and spermatogonia to cause spermatogenesis failure. After that, we excluded the influence of factors such as the PD\u2010L1 receptor and humoral regulation, confirming that PD\u2010L1\u00a0has an intrinsic function to interact with PD\u2010L1. Studies have shown that PD\u2010L1 not only serves as a ligand but also plays a receptor\u2010like role in signal transduction. PD\u2010L1 interacts with PD\u2010L1 to affect the adhesive function of germ cells, causing malformation and spermatid sloughing. Taken together, these results indicate that PD\u2010L1 can interact with PD\u2010L1 to cause germ cell detachment and male infertility.<\/jats:p>","DOI":"10.1111\/jcmm.17305","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T09:31:42Z","timestamp":1649151102000},"page":"2908-2920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Overexpression of PD\u2010L1 causes germ cells to slough from mouse seminiferous tubules via the PD\u2010L1\/PD\u2010L1 interaction"],"prefix":"10.1111","volume":"26","author":[{"given":"Lian","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Neurobiology School of Medicine South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences LKS faculty of Medicine The University of Hong 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