{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:36:18Z","timestamp":1781278578742,"version":"3.54.1"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1002804"],"award-info":[{"award-number":["2018YFC1002804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early spontaneous abortion (ESA) is one of the most common complications during pregnancy and the inflammation condition in uterine environment such as long\u2010term exposure to high TNF\u03b1 plays an essential role in the aetiology. Ferritin heavy chain (FTH1) is considered to be closely associated with inflammation and very important in normal pregnancy, yet the underlying mechanism of how TNF\u03b1 induced abortion and its relationship with FTH1 remain elusive. In this study, we found that TNF\u03b1 and FTH1 were positively expressed in decidual stromal cells and increased significantly in the ESA group compared with the normal pregnancy group (NP group). Besides, TNF\u03b1 expression was positively correlated with FTH1 expression. Furthermore, in vitro cell model demonstrated that high TNF\u03b1 could induce the abnormal signals of TNFR\/NF\u2010\u03baB\/FTH1 and activate apoptosis both in human endometrium stromal cells (hESCs) and in local decidual tissues. Taken together, the present findings suggest that the excessive apoptosis in response to TNF\u03b1\u2010induced upregulation of FTH1\u00a0may be responsible for the occurrence of ESA, and thus provide a possible therapeutic target for the treatment of ESA.<\/jats:p>","DOI":"10.1111\/jcmm.17308","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T07:40:15Z","timestamp":1650440415000},"page":"2947-2958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["TNF\u03b1\u2010induced abnormal activation of TNFR\/NF\u2010\u03baB\/FTH1 in endometrium is involved in the pathogenesis of early spontaneous abortion"],"prefix":"10.1111","volume":"26","author":[{"given":"Yuting","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Obstetrics\/Gynecology Joint Laboratory of Reproductive Medicine (SCU\u2010CUHK) Key Laboratory of Obstetric Gynecologic and Pediatric Diseases and Birth 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