{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T17:47:46Z","timestamp":1776361666787,"version":"3.51.2"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since ancient times, plants have been used as green bioresources to ensure a healthier life by recovering from different diseases. Kattosh (<jats:italic>Lasia spinosa<\/jats:italic> L. Thwaites) is a local plant with various traditional uses, especially for arthritis, constipation and coughs. This research investigated the effect of Kattosh stem extract (LSES) on streptozotocin\u2010induced damage to the pancreas, kidney, and liver using in vitro, in vivo and in silico methods. In vitro phytochemical, antioxidative and anti\u2010inflammatory effects of LSES were accomplished by established methods followed by antidiabetic actions in in vivo randomized controlled intervention in STZ\u2010induced animal models for four weeks. In an in silico study, LSES phytocompounds interacted with antidiabetic receptors of peroxisome proliferator\u2010activated receptor\u2010gamma (PPAR, PDB ID: 3G9E), AMP\u2010activated protein kinase (AMPK, PDB ID: 4CFH) and \u03b1\u2010amylase enzyme (PDB ID: 1PPI) to verify the in vivo results. In addition, LSES showed promising in vitro antioxidative and anti\u2010inflammatory effects. In contrast, it showed a decrease in weekly blood glucose level, normalized lipid profile, ameliorated liver and cardiac markers, managed serum AST and ALT levels, and increased glucose tolerance ability in the animal model study. Restoration of pancreatic and kidney damage was reflected by improving histopathological images. In ligand\u2013receptor interaction, ethyl \u03b1\u2010d\u2010glucopyranoside of Kattosh showed the highest affinity for the \u03b1\u2010amylase enzyme, PPAR, and AMPK receptors. Results demonstrate that the affinity of Kattosh phytocompounds potentially attenuates pancreatic and kidney lesions and could be approached as an alternative antidiabetic source with further clarification.<\/jats:p>","DOI":"10.1111\/jcmm.17339","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T06:35:29Z","timestamp":1651559729000},"page":"3343-3363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Incredible affinity of Kattosh with PPAR\u2010\u03b3 receptors attenuates STZ\u2010induced pancreas and kidney lesions evidenced in chemicobiological interactions"],"prefix":"10.1111","volume":"26","author":[{"given":"Md. Mamunur","family":"Rashid","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Chittagong  Chittagong Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4902-8923","authenticated-orcid":false,"given":"Md. Atiar","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Chittagong  Chittagong Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Shahidul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Chittagong  Chittagong Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2850-1635","authenticated-orcid":false,"given":"Md. Amjad","family":"Hossen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Science and Engineering International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1457-0245","authenticated-orcid":false,"given":"A. S. M. Ali","family":"Reza","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Science and Engineering International Islamic University Chittagong  Chittagong Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M. Abu","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology University of Chittagong  Chittagong Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afnan M.","family":"Alnajeebi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry College of Science University of Jeddah  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nouf Abubakr","family":"Babteen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry College of Science University of Jeddah  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mala","family":"Khan","sequence":"additional","affiliation":[{"name":"Bangladesh Reference Institute for Chemical Measurements (BRiCM)  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salama Mostafa","family":"Aboelenin","sequence":"additional","affiliation":[{"name":"Biology Department Turabah University College Taif University  Taif Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Mohamed","family":"Soliman","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Sciences Department Turabah University College Taif University  Taif Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa H.","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Physiology College of Medicine King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hend F.","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Department of Food Science and Human Nutrition College of Agriculture and Veterinary Medicine Qassim University  Buraidah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399052952587"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100379"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(12)60032-X"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399816666201103143225"},{"key":"e_1_2_9_7_1","first-page":"1269","article-title":"Antinociceptive, anti\u2010inflammatory and anti\u2010diarrheal activities of the hydroalcoholic extract of Lasia spinosa Linn. 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