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In this study, we investigated effects of IM156 against polymicrobial sepsis. Administration of IM156\u00a0significantly increased survival rate against caecal ligation and puncture (CLP)\u2010induced sepsis. Mechanistically, IM156\u00a0markedly reduced viable bacterial burden in the peritoneal fluid and peripheral blood and attenuated organ damage in a CLP\u2010induced sepsis model. IM156 also inhibited the apoptosis of splenocytes and the production of inflammatory cytokines including IL\u20101\u03b2, IL\u20106 and IL\u201010 in CLP mice. Moreover, IM156\u00a0strongly inhibited the generation of reactive oxygen species and subsequent formation of neutrophil extracellular traps in response to lipopolysaccharide in neutrophils. Taken together, these results show that IM156 can inhibit inflammatory response and protect against polymicrobial sepsis, suggesting that IM156\u00a0might be a new treatment for sepsis.<\/jats:p>","DOI":"10.1111\/jcmm.17341","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T06:40:25Z","timestamp":1651560025000},"page":"3378-3386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["IM156, a new AMPK activator, protects against polymicrobial sepsis"],"prefix":"10.1111","volume":"26","author":[{"given":"Ji Hyeon","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Kyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical 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