{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T17:12:17Z","timestamp":1778433137637,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T00:00:00Z","timestamp":1652832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tendinopathy is mainly characterized by local pain, functional limitation and decreased athletic ability, which seriously affects the quality of life of patients and the career of athletes. Farrerol (FA), one of the main active compounds extracted from <jats:italic>Rhododendron<\/jats:italic> and plants in the <jats:italic>Rhododendron<\/jats:italic> family, has a wide range of pharmacological activities, such as immunomodulatory, anti\u2010inflammatory and antiviral effects. However, the effect of FA on tendinopathy is unclear. Here, we investigated the pharmacological effect and mechanism of FA in tendon injury through collagenase\u2010induced tendinopathy <jats:italic>in vivo<\/jats:italic> and RSL3\u2010induced tenocytes injury <jats:italic>in vitro<\/jats:italic>. The results showed that FA alleviated the infiltration of inflammatory cells, promoted tenogenesis and improved mechanical properties of the Achilles tendon in rats. In addition, ferroptosis inducer RSL3 inhibits the tenogenesis <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>, which accelerates the progression of tendinopathy. Moreover, FA effectively inhibited iron accumulation and alleviated ferroptosis in the Achilles tendon. Using <jats:italic>in vitro<\/jats:italic> experiments, we found that FA antagonized ferroptosis by reducing lipid peroxidation and iron accumulation in tenocytes. Finally, we found that glutathione peroxidase 4\u00a0silencing could block the protective effect of FA on ferroptosis of tenocytes. Therefore, the results of this study suggest that FA can relieve collagenase\u2010induced tendinopathy by inhibiting ferroptosis, and reveal that FA may be a potentially effective drug for the treatment of tendinopathy in the future.<\/jats:p>","DOI":"10.1111\/jcmm.17388","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T08:54:57Z","timestamp":1652864097000},"page":"3483-3494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Farrerol alleviates collagenase\u2010induced tendinopathy by inhibiting ferroptosis in rats"],"prefix":"10.1111","volume":"26","author":[{"given":"Yongfu","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pharmacy Yuebei People's Hospital Affiliated to Shantou University Medical College  Shaoguan Guangdong 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