{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:29:36Z","timestamp":1770744576474,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HA6145\/6\u20101"],"award-info":[{"award-number":["HA6145\/6\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Classic Hodgkin lymphoma (cHL) is usually characterized by a low tumour cell content, derived from crippled germinal centre B cells. Rare cases have been described in which the tumour cells show clonal T\u2010cell receptor rearrangements. From a clinicopathological perspective, it is unclear if these cases should be classified as cHL or anaplastic large T\u2010cell lymphoma (ALCL). Since we recently observed differences in the motility of ALCL and cHL tumour cells, here, we aimed to obtain a better understanding of T\u2010cell\u2010derived cHL by investigating their global proteomic profiles and their motility. In a proteomics analysis, when only motility\u2010associated proteins were regarded, T\u2010cell\u2010derived cHL cell lines showed the highest similarity to ALK<jats:sup>\u2212<\/jats:sup> ALCL cell lines. In contrast, T\u2010cell\u2010derived cHL cell lines presented a very low overall motility, similar to that observed in conventional cHL. Whereas all ALCL cell lines, as well as T\u2010cell\u2010derived cHL, predominantly presented an amoeboid migration pattern with uropod at the rear, conventional cHL never presented with uropods. The migration of ALCL cell lines was strongly impaired upon application of different inhibitors. This effect was less pronounced in cHL cell lines and almost invisible in T\u2010cell\u2010derived cHL. In summary, our cell line\u2010derived data suggest that based on proteomics and migration behaviour, T\u2010cell\u2010derived cHL is a neoplasm that shares features with both cHL and ALCL and is not an ALCL with low tumour cell content. Complementary clinical studies on this lymphoma are warranted.<\/jats:p>","DOI":"10.1111\/jcmm.17389","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T07:21:40Z","timestamp":1652944900000},"page":"3495-3505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["T\u2010cell\u2010derived Hodgkin lymphoma has motility characteristics intermediate between Hodgkin and anaplastic large cell lymphoma"],"prefix":"10.1111","volume":"26","author":[{"given":"Julia","family":"Bein","sequence":"first","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology Goethe University Frankfurt am Main  Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Flinner","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology Goethe University Frankfurt am Main  Frankfurt am Main Germany"},{"name":"Frankfurt Cancer 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Institut Pierre Gilles de Gennes PSL Research University CNRS UMR 144  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Oellerich","sequence":"additional","affiliation":[{"name":"Frankfurt Cancer Institute Goethe University  Frankfurt am Main Germany"},{"name":"Department of Internal Medicine 2 Goethe University Hospital  Frankfurt Germany"},{"name":"German Cancer Consortium\/German Cancer Research Center  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3424-1091","authenticated-orcid":false,"given":"Sylvia","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Pathology Goethe University Frankfurt am Main  Frankfurt am Main 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