{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:53:41Z","timestamp":1785387221860,"version":"3.55.0"},"reference-count":65,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92068206"],"award-info":[{"award-number":["92068206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>LECT2 (leucocyte cell\u2010derived chemotaxin 2) is a 16\u2010kDa protein mainly produced by hepatocytes. It was first isolated in PHA\u2010activated human T\u2010cell leukaemia SKW\u20103 cells and originally identified as a novel neutrophil chemotactic factor. However, many lines of studies suggested that LECT2 was a pleiotropic protein, it not only functioned as a cytokine to exhibit chemotactic property, but also played multifunctional roles in some physiological conditions and pathological abnormalities, involving liver regeneration, neuronal development, HSC(haematopoietic stem cells) homeostasis, liver injury, liver fibrosis, hepatocellular carcinoma, metabolic disorders, inflammatory arthritides, systemic sepsis and systemic amyloidosis. Among the above studies, it was discovered that LECT2 could be a promising molecular biomarker and therapeutic target. This review summarizes LECT2\u2010related receptors and pathways, basic and clinical researches, primarily in mice and human, for a better comprehension and management of these diseases in the future.<\/jats:p>","DOI":"10.1111\/jcmm.17407","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T09:39:33Z","timestamp":1654249173000},"page":"3598-3607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["<scp>LECT2<\/scp>: A pleiotropic and promising hepatokine, from bench to bedside"],"prefix":"10.1111","volume":"26","author":[{"given":"Yuan","family":"Xie","sequence":"first","affiliation":[{"name":"General Surgery Center, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine Zhujiang Hospital, Southern Medical University  Guangzhou China"},{"name":"Department of General Surgery II The First People's Hospital of Zhaoqing  Zhaoqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai\u2010Wei","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cerebrovascular Disease The First People's Hospital of Zhaoqing  Zhaoqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Xing","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Basic Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Basic Medical Sciences Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Gao","sequence":"additional","affiliation":[{"name":"General Surgery Center, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine Zhujiang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0021-9454","authenticated-orcid":false,"given":"Wei\u2010Jie","family":"Zhou","sequence":"additional","affiliation":[{"name":"General Surgery Center, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine Zhujiang Hospital, Southern Medical University  Guangzhou China"},{"name":"Department of Pathology, School of Basic Medical Sciences Southern Medical University  Guangzhou China"},{"name":"Department of General Surgery &amp; Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, First Clinical Medical College Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(96)02572-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1997.5198"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2013.01.008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.01.025"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.720375"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(97)00181-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1998.tb03855.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.24.425"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.28.247"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2004.07.007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.11.010"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32833a7d6f"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12719"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.1.579"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2017.09.011"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.021"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32299"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.749648"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v13.i12.2071"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20286"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.1999.00836.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30140"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098817"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31398"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26738"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2011.5"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.08.117"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173310"},{"issue":"6","key":"e_1_2_7_30_1","first-page":"276","article-title":"Increased serum leukocyte cell\u2010derived chemotaxin 2 (LECT2) levels in obesity and fatty liver","volume":"7","author":"Okumura A","year":"2013","journal-title":"Biosci Trends"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0728"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.08.098"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80689-0"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.06.001"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1530\/jme-17-0267"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200006)43:6<1419::AID-ANR28>3.0.CO;2-I"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.37.22657"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00291-3"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23215"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.4238\/gmr15048889"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121466"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2010.08.002"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2012.00488.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-517938"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2014.964858"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.152"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.9"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10491012"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.11"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.558"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.08.013"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2011.574354084"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100446"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27635"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27696"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.01.061"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12310"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2011.30"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2019.05.002"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(07)96002-2"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0603252"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0622-8"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050715"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.6.2043"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-318220"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705147"}],"container-title":["Journal of Cellular and Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.17407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcmm.17407","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcmm.17407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T07:22:06Z","timestamp":1692861726000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcmm.17407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,3]]},"references-count":65,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/jcmm.17407"],"URL":"https:\/\/doi.org\/10.1111\/jcmm.17407","archive":["Portico"],"relation":{},"ISSN":["1582-1838","1582-4934"],"issn-type":[{"value":"1582-1838","type":"print"},{"value":"1582-4934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,3]]},"assertion":[{"value":"2021-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}