{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T05:01:48Z","timestamp":1781326908353,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007234","name":"University of Chicago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007234","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Stimulator of interferon genes (STING) is reported to exert vital functions in inflammatory responses and autoimmune diseases. Nevertheless, the status and roles of STING in oral lichen planus (OLP) remain elusive. Here, we state that STING and its downstream cytokine interferon\u2010\u03b2 (IFN\u03b2) expression is boosted in the oral keratinocytes from patients suffering OLP in comparison with those from healthy participants. Mechanistically, transcription factor GATA\u2010binding protein 1 (GATA1) which is highly increased in diseased samples specifically interacts with its element in the promoter of <jats:italic>STING<\/jats:italic> to enhance STING transcripts. 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>, the active form of vitamin D, is capable of restricting STING and IFN\u03b2 increases in oral keratinocyte models resembling OLP in vitro. Moreover, there is a negative correlation between vitamin D receptor (VDR) and STING or IFN\u03b2 in human samples. Using plasmids and small interfering RNA transfection technologies, we find 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> regulates STING and IFN\u03b2 through a mechanism controlled by the hypoxia\u2010inducible factor\u20101\u03b1 (HIF\u20101\u03b1)\u2010GATA1 axis. Collectively, our findings unveil that 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> lowers STING and IFN\u03b2 overexpression in the context of OLP.<\/jats:p>","DOI":"10.1111\/jcmm.17409","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T05:59:51Z","timestamp":1653890391000},"page":"3751-3759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["1,25(<scp>OH<\/scp>)<scp><sub>2<\/sub>D<sub>3<\/sub><\/scp> blocks <scp>IFN\u03b2<\/scp> production through regulating <scp>STING<\/scp> in epithelial layer of oral lichen planus"],"prefix":"10.1111","volume":"26","author":[{"given":"Xuejun","family":"Ge","sequence":"first","affiliation":[{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Shanxi Medical University School and Hospital of Stomatology  Taiyuan Shanxi China"},{"name":"Department of Endodontics Shanxi Medical University School and Hospital of Stomatology  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxian","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Shanxi Medical University School and Hospital of Stomatology  Taiyuan Shanxi China"},{"name":"Department of Endodontics Shanxi Medical University School and Hospital of Stomatology  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanting","family":"Xie","sequence":"additional","affiliation":[{"name":"Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Shanxi Medical University School and Hospital of Stomatology  Taiyuan Shanxi China"},{"name":"Department of Pathology Shanxi Medical University  Taiyuan Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Li","sequence":"additional","affiliation":[{"name":"Shanxi Province Key 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