{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:48:14Z","timestamp":1762300094733,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T00:00:00Z","timestamp":1654992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["991054"],"award-info":[{"award-number":["991054"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate the frequency and prognosis of runt\u2010related transcription factor 1 (RUNX1) and additional sex combs like\u20101 (ASXL1) mutations in acute myeloid leukaemia (AML) patients in northeastern Iran. This cross\u2010sectional study was performed on 40 patients with AML (including 35 patients with denovo AML and five patients with secondary AML) from February 2018 to February 2021. All patients were followed up for 36\u2009months. We evaluated the frequency and survival rate of RUNX1 and ASXL1 mutations in AML patients. To detect mutations, peripheral blood samples and bone marrow aspiration were taken from all participants. One male patient (2.5%) had RUNX1 mutations and four cases (10%; 3 females vs. 1 male) had ASXL1 mutations. The survival rates of AML patients after 1, 3, 6, 9, 12, 24 and 36\u2009months were 98%, 90%, 77%, 62%, 52%, 27% and 20%, respectively. There was a significant relationship between the occurrence of ASXL1 mutations and the survival of patients with AML (<jats:italic>p<\/jats:italic>\u00a0=\u20090.027). Also, there was a significant relationship between the incidence of death and haemoglobin levels in patients with AML (<jats:italic>p<\/jats:italic>\u00a0=\u20090.045). Thus, with an increase of one unit in patients' haemoglobin levels, the risk of death is reduced by 16.6%. Patients with AML had a high mortality rate, poor therapy outcome and low survival rate. ASXL1 and RUNX1 mutations are associated with a worse prognosis in patients with newly diagnosed AML. Also, we witnessed that the prevalence of ASXL1 to RUNX1 mutations was higher in northeastern Iran compared with other regions.<\/jats:p>","DOI":"10.1111\/jcmm.17424","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T03:58:53Z","timestamp":1655092733000},"page":"3797-3801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluating the frequency, prognosis and survival of <scp>RUNX1<\/scp> and <scp>ASXL1<\/scp> mutations in patients with acute myeloid leukaemia in northeastern Iran"],"prefix":"10.1111","volume":"26","author":[{"given":"Mohammad","family":"Parsa\u2010kondelaji","sequence":"first","affiliation":[{"name":"Department of Hematology and Blood Banking Faculty of Medical Sciences Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Ayatollahi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Banking Cancer Molecular Pathology Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrdad","family":"Rostami","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Banking Faculty of Medical Sciences Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Sheikhi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Banking Cancer Molecular Pathology Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faezeh","family":"Barzegar","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Banking Faculty of Medical Sciences Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monnavar","family":"Afzalaghaee","sequence":"additional","affiliation":[{"name":"Social Determinant of Health Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elmira","family":"Moradi","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Banking Cancer Molecular Pathology Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3158-6983","authenticated-orcid":false,"given":"Mohammad Hadi","family":"Sadeghian","sequence":"additional","affiliation":[{"name":"Department of Hematology and Blood Banking Cancer Molecular Pathology Research Center Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4376-1083","authenticated-orcid":false,"given":"Amir Abbas","family":"Momtazi\u2010Borojeni","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology Faculty of Medicine, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,12]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1016\/j.blre.2019.04.005"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1080\/16078454.2021.1905356"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1200\/JCO.2016.71.2208"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1084\/jem.20160927"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1002\/cncr.32566"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1093\/ajcp\/aqx046"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.2741\/3977"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.3324\/haematol.2012.064667"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.3390\/ijms18081618"},{"key":"e_1_2_10_11_1","first-page":"145","article-title":"RUNX1 mutations in acute myeloid leukemia (AML): correlation with distinct cytogenetic subgroups and clinical outcome. 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