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This study aimed to examine the effects of syringic acid on isoproterenol\u2010treated mice and cells. Syringic acid mitigated the isoproterenol\u2010induced upregulation of heart weight to bodyweight ratio, pathological cardiac remodelling and fibrosis in mice. Picrosirius red staining, quantitative real\u2010time polymerase chain reaction (qRT\u2010PCR) and Western blotting analyses revealed that syringic acid markedly downregulated collagen accumulation and fibrosis\u2010related factors, including Fn1. The results of RNA sequencing analysis of <jats:italic>Ereg<\/jats:italic> expression were verified using qRT\u2010PCR. Syringic acid or transfection with si\u2010<jats:italic>Ereg<\/jats:italic> mitigated the isoproterenol\u2010induced upregulation of Ereg, Myc and Ngfr. <jats:italic>Ereg<\/jats:italic> knockdown mitigated the isoproterenol\u2010induced upregulation of Nppb and Fn1 and enhancement of cell size. Mechanistically, syringic acid alleviated cardiac hypertrophy and fibrosis by downregulating Ereg. These results suggest that syringic acid is a potential therapeutic agent for cardiac hypertrophy and fibrosis.<\/jats:p>","DOI":"10.1111\/jcmm.17449","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T06:25:00Z","timestamp":1655706300000},"page":"4076-4086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Syringic acid mitigates isoproterenol\u2010induced cardiac hypertrophy and fibrosis by downregulating Ereg"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8650-2954","authenticated-orcid":false,"given":"Xiongyi","family":"Han","sequence":"first","affiliation":[{"name":"Heart Research Center of Chonnam National University Hospital  Gwangju Korea"},{"name":"Hypertension Heart Failure Research Center Chonnam National University Hospital  Gwangju 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