{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:35:31Z","timestamp":1790534131809,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Becker muscular dystrophy (BMD) is an X\u2010linked neuromuscular disorder due to mutation in the <jats:italic>DMD<\/jats:italic> gene, encoding dystrophin. Despite a wide clinical variability, BMD is characterized by progressive muscle degeneration and proximal muscle weakness. Interestingly, a dysregulated expression of muscle\u2010specific microRNAs (miRNAs), called myomirs, has been found in patients affected with muscular dystrophies, although few studies have been conducted in BMD. We analysed the serum expression levels of a subset of myomirs in a cohort of 29 ambulant individuals affected by BMD and further classified according to the degree of alterations at muscle biopsy and in 11 age\u2010matched healthy controls. We found a significant upregulation of serum miR\u20101, miR\u2010133a, miR\u2010133b and miR\u2010206 in our cohort of BMD patients, supporting the role of these miRNAs in the pathophysiology of the disease, and we identified serum cut\u2010off levels discriminating patients from healthy controls, confiming the potential of circulating miRNAs as promising noninvasive biomarkers. Moreover, serum levels of miR\u2010133b were found to be associated with fibrosis at muscle biopsy and with patients' motor performances, suggesting that miR\u2010133b might be a useful prognostic marker for BMD patients. Taken together, our data showed that these serum myomirs may represent an effective tool that may support stratification of BMD patients, providing the opportunity of both monitoring disease progression and assessing the treatment efficacy in the context of clinical trials.<\/jats:p>","DOI":"10.1111\/jcmm.17462","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T08:42:17Z","timestamp":1658824937000},"page":"4678-4685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>MicroRNAs<\/scp> as serum biomarkers in Becker muscular dystrophy"],"prefix":"10.1111","volume":"26","author":[{"given":"Delia","family":"Gagliardi","sequence":"first","affiliation":[{"name":"Neurology Unit IRCCS Foundation Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"},{"name":"Department of Pathophysiology and Transplantation, Dino Ferrari Center University of Milan  Milan 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