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Nonimmune factors such as reactive oxygen species and inflammation have been considered as the primary driving force for graft failure. The adipokine adiponectin plays potent roles against inflammation and oxidative stress. Previous studies have demonstrated that systemic administration of adiponectin significantly prevented islet loss and enhanced islet function at post\u2010transplantation period. In vitro studies indicate that adiponectin protects islets from hypoxia\/reoxygenation injury, oxidative stress as well as TNF\u2010\u03b1\u2010induced injury. By applying adenovirus mediated transfection, we now engineered islet cells to express exogenous <jats:italic>adiponectin<\/jats:italic> gene prior to islet transplantation. Adenovirus\u2010mediated adiponectin transfer to a syngeneic suboptimal islet graft transplanted under kidney capsule markedly prevented inflammation, preserved islet graft mass and improved islet transplant outcomes. These results suggest that adenovirus\u2010mediated <jats:italic>adiponectin<\/jats:italic> gene therapy would be a beneficial clinical engineering approach for islet preservation in islet transplantation.<\/jats:p>","DOI":"10.1111\/jcmm.17515","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T07:41:10Z","timestamp":1660722070000},"page":"4847-4858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Adiponectin gene therapy prevents islet loss after transplantation"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0650-4109","authenticated-orcid":false,"given":"Chengshi","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Transplant Engineering and Immunology, Department of Endocrinology and Metabolism, West China Hospital Sichuan University  Chengdu China"},{"name":"Department of Endocrinology and Metabolism, Center for 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