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Endothelial colony\u2010forming cells (ECFCs) represent a cellular population of the endothelial lineage with proliferative capacity and vasoreparative properties. This study aimed to evaluate the angiogenic capacity of ECFCs of patients with granulomatosis with polyangiitis (GPA). The ECFCs of 13 patients with PR3\u2010positive GPA and 14 healthy controls were isolated and characterized using fluorescence\u2010activated cell sorting, capillary tube formation measurement, scratching assays and migration assays with and without plasma stimulation. Furthermore, three patients with active disease underwent post\u2010treatment recollection of ECFCs for longitudinal evaluation. The ECFCs from the patients and controls showed similar capillary structure formation. However, the ECFCs from the patients with inactive GPA exhibited early losses of angiogenic capacity. Impairments in the migration capacities of the ECFCs were also observed in patients with GPA and controls (12th h, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.05). Incubation of ECFCs from patients with GPA in remission with plasma from healthy controls significantly decreased migration capacity (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0001). Longitudinal analysis revealed that treatment significantly lowered ECFC migration rates. This study revealed that ECFCs from the patients with PR3\u2010positive GPA in remission demonstrated early losses of tube formation and reduced migration capacity compared to those of the healthy controls, suggesting impairment of endothelial function.<\/jats:p>","DOI":"10.1111\/jcmm.17531","type":"journal-article","created":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T09:11:33Z","timestamp":1662109893000},"page":"5044-5053","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impaired repair properties of endothelial colony\u2010forming cells in patients with granulomatosis with polyangiitis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2874-0268","authenticated-orcid":false,"given":"Ana Paula Toledo","family":"Del Rio","sequence":"first","affiliation":[{"name":"Rheumatology Discipline, School of Medical Sciences University of Campinas (UNICAMP)  Campinas 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