{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:18:00Z","timestamp":1789647480413,"version":"4.0.0"},"reference-count":33,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803146"],"award-info":[{"award-number":["81803146"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>One of the earliest events in the development of psoriatic lesion is a vascular network expansion. The abnormal vascular network is associated with increased endothelial cells (ECs) survival, proliferation, adhesion, migration, angiogenesis and permeability in psoriatic lesion. Our previous study demonstrated that epidermal growth factor\u2010like repeats and discoidin I\u2010like domains 3 (EDIL3) derived from psoriatic dermal mesenchymal stem cells (DMSCs) promoted cell\u2013cell adhesion, migration and angiogenesis of ECs, but the molecular mechanism of upstream or downstream has not been explored. So, this study aimed to explore the association between EDIL3 derived from DMSCs (DMSCs\u2010derived EDIL3) and psoriasis\u2010associated angiogenesis. We injected recombinant EDIL3 protein to mouse model of psoriasis to confirm the roles of EDIL3 in psoriasis. Besides, we employed both short\u2010interference RNA (si\u2010RNA) and lentiviral vectors to explore the molecular mechanism of EDIL3 promoting angiogenesis in psoriasis. In vivo, this research found that after injected recombination EDIL3 protein, the epidermis thickness and microvessel density were both elevated. EDIL3 accelerated the process of psoriasis in the IMQ\u2010induced psoriasis\u2010like mouse model. Additionally, we confirmed that in vitro DMSCs\u2010derived EDIL3 is involved in the tube formation of ECs via \u03b1v\u03b23\u2010FAK\/MEK\/ERK signal pathway. This suggested that DMSCs\u2010derived EDIL3 and \u03b1v\u03b23\u2010FAK\/MEK\/ERK signal pathway in ECs play an important role in the pathogenesis of psoriasis. And the modification of DMSCs, EDIL3 and \u03b1v\u03b23\u2010FAK\/MEK\/ERK signal pathway will provide a valuable therapeutic target to control the angiogenesis in psoriasis.<\/jats:p>","DOI":"10.1111\/jcmm.17544","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T10:19:58Z","timestamp":1662459598000},"page":"5202-5212","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["<scp>EDIL3<\/scp> influenced the <scp>\u03b1v\u03b23\u2010FAK<\/scp>\/<scp>MEK<\/scp>\/<scp>ERK<\/scp> axis of endothelial cells in psoriasis"],"prefix":"10.1111","volume":"26","author":[{"given":"Xuping","family":"Niu","sequence":"first","affiliation":[{"name":"Shanxi Key Laboratory of Stem Cells for Immunological Dermatosis, Institute of Dermatology Taiyuan Central Hospital of Shanxi Medical University  Taiyuan Shanxi 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