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To further explore the mechanisms of action of AVP, we compared the PFC transcriptome changes before and after AVP treatment in VPA\u2010induced autism rat model. The autism model was induced by intraperitoneally injected with VPA at embryonic day 12.5 and randomly assigned to two groups: the VPA\u2010induced autism model group and the AVP treatment group. The AVP treatment group were treated with intranasal AVP at postnatal day 21 and for 3\u2009weeks. The gene expression levels and function changes on the prefrontal cortex were measured by RNA\u2010seq and bioinformatics analysis at PND42 and the mRNA expression levels of synaptic and myelin development related genes were validated by qPCR. 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