{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:12:50Z","timestamp":1792271570884,"version":"4.4.0"},"reference-count":57,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002660","name":"Islamic Azad University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002660","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, nanoniosome\u2010loaded <jats:italic>Myristica fragrans<\/jats:italic>' (MF) phenolic compounds (NLMP) were synthesized and characterized for their physical properties, and hepatoprotective effects on mice with liver toxicity induced by L\u2010asparaginase (LA) injection. According to the results, NLMP has a spherical shape with a 263\u2009nm diameter, a zeta potential of \u221226.55\u2009mV and a polydispersity index (PDI) of 0.192. The weight and feed intake of mice induced with hepatotoxicity were significantly (<jats:italic>p<\/jats:italic>\u00a0\u2264\u20090.05) increased after they were treated with NLMP (2.5\u00a0mg\/kg body weight of mice). In addition, the blood levels of triglyceride (TG), cholesterol (Chol), liver enzymes (aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP)) and total bilirubin were significantly (<jats:italic>p<\/jats:italic>\u00a0\u2264\u20090.05) decreased. A significant increase (<jats:italic>p<\/jats:italic>\u00a0\u2264\u20090.05) in the blood levels of the antioxidant defence system (glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (CAT)) were also reported after NLMP treatment. NLMP was also led to a significant decrease (<jats:italic>p<\/jats:italic>\u00a0\u2264\u20090.05) in inflammatory\u2010related gene expression of inducible nitric oxide synthase (iNOS) and Interferon\u2010gamma (IFN\u2010\u03b3) in the liver, as well as a meaningful (<jats:italic>p<\/jats:italic>\u00a0\u2264\u20090.05) increase in the expression of SOD as an antioxidant status biomarker. Consequently, the NLMP is recommended as a potential dietary supplement to alleviate the symptoms of LA\u2010induced hepatotoxicity.<\/jats:p>","DOI":"10.1111\/jcmm.17581","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T06:54:07Z","timestamp":1665644047000},"page":"5517-5527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Hepatoprotective effect of nanoniosome loaded <i>Myristica fragrans<\/i> phenolic compounds in mice\u2010induced hepatotoxicity"],"prefix":"10.1111","volume":"26","author":[{"given":"Mahsa Rastegar Moghaddam","family":"Poorbagher","sequence":"first","affiliation":[{"name":"Department of Biology, Mashhad Branch Islamic Azad University  Mashhad 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