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Our study explored the effect of 1,25(OH)2D3 treatment on the expression of monocyte chemotactic protein\u20101 (MCP\u20101), hepatocyte growth factor (HGF), and insulin\u2010like growth factor\u20101 (IGF\u20101) by peripheral blood mononuclear cells (PBMCs), peritoneal fluid mononuclear cells (PFMCs), endometrial stromal cells (ESCs), and its effect on the proliferation of PBMCs and PFMCs of patients with endometriosis compared with controls. PBMCs, PFMCs, and ESCs were obtained from 10 endometriosis patients and 10 non\u2010endometriotic individuals. After treating cells with 0.1\u00a0\u03bcM of 1,25(OH)2D3 for 6, 24, and 48\u2009h, the gene and protein expression of mentioned factors were evaluated by real\u2010time PCR and ELISA methods, respectively. 1,25(OH)2D3 treatment significantly reduced the protein expression of MCP\u20101, HGF, and IGF\u20101 in PBMCs and PFMCs of endometriotic patients at 48\u2009h (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05\u2013&lt;0.01). Also, this treatment significantly reduced <jats:italic>MCP\u20101<\/jats:italic>, <jats:italic>HGF<\/jats:italic>, and <jats:italic>IGF\u20101<\/jats:italic> gene and\/or protein expression in EESCs and EuESCs at 24 and 48\u2009h (<jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.05\u2013&lt;0.01). 1,25(OH)2D3 treatment also reduced the proliferation of PBMCs and PFMCs of endometriotic patients compared with controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). 1,25(OH)2D3 can be considered as a potentially effective agent in the prevention and treatment of endometriosis along with other therapies.<\/jats:p>","DOI":"10.1111\/jcmm.17592","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T08:14:35Z","timestamp":1666167275000},"page":"5634-5646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Changes in MCP\u20101, HGF, and IGF\u20101 expression in endometrial stromal cells, PBMCs, and PFMCs of endometriotic women following 1,25(OH)2D3 treatment"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4573-4900","authenticated-orcid":false,"given":"Sahel","family":"Heidari","sequence":"first","affiliation":[{"name":"Immunology Research Center, Institute of Immunology and Infectious Diseases Iran University of Medical Sciences  Tehran Iran"},{"name":"Department of Immunology, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7234-4812","authenticated-orcid":false,"given":"Roya","family":"Kolahdouz\u2010Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health Iran University of Medical Sciences  Tehran 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