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MARCO is a surface receptor of macrophage involving in tissue inflammation and immune disorders. Moreover, polyguanine (PolyG) is considered to bind to macrophage receptor with collagenous structure (MARCO). However, the role of MARCO and PolyG in the development and treatment of AIH still remains unclear. Therefore, this study explores the expression of MARCO and therapeutic activity of PolyG in both S100\u2010induced AIH in mouse and Lipopolysaccharide (LPS)\u2010treated macrophage (RAW264.7 cells). Moreover, there were significant increases in inflammatory factors and MARCO, as well as decrease in I\u2010kappa\u2010B\u2010alpha (Ik\u2010B) in the liver of AIH mice and LPS\u2010induced cells. However, PolyG treatment significantly reversed the elevation of inflammatory cytokins, MARCO and reduction of Ik\u2010B. In addition, PolyG treatment could downregulate the expression of Toll\u2010like receptor 4 (TLR4) and TIR\u2010domain\u2010containing adaptor inducing interferon\u2010\u03b2 (TRIF), decrease macrophage M1 polarization and increase macrophage M2 polarization. When hepatocytes were co\u2010cultured with different treatment of macrophages, similar expression profile of inflammatory cytokines was observed in hepatocytes. The research revealed that MARCO expression was elevated in AIH mice. PolyG treatment and inhibition of MARCO significantly reduced inflammatory cytokines expression in the liver as well as hepatocytes and macrophages. Therefore, MARCO could be a target for the treatment of AIH.<\/jats:p>","DOI":"10.1111\/jcmm.17599","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T17:50:54Z","timestamp":1666720254000},"page":"5690-5701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Polyguanine alleviated autoimmune hepatitis through regulation of macrophage receptor with collagenous structure and TLR4\u2010TRIF\u2010NF\u2010\u03baB signalling"],"prefix":"10.1111","volume":"26","author":[{"given":"Tingchen","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, Wenzhou Key Laboratory of Hepatology, Hepatology Institute of Wenzhou Medical University The First Affiliated Hospital of Wenzhou Medical University  Wenzhou 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