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Intraocular pressure (IOP) generates mechanical strain on sclera. Recent studies have demonstrated that sclera, especially the peripapillary sclera, undergoes complicated remodelling under the mechanical strain. However, the mechanisms of the hypertensive scleral remodelling in human eyes remained uncertain. In this study, peripapillary human scleral fibroblasts (ppHSFs) were applied cyclic mechanical strain by Flexcell\u20105000\u2122 tension system. We found that CXC\u2010 ligands and CXCR2 were differentially expressed after strain. Increased cell proliferation and inhibited cell motility were observed when CXCR2 was upregulated under the strain, whereas cell proliferation and motility did not have a significant change when CXCR2 was knocked down. CXCR2 could facilitate cell proliferation ability, modulate the mRNA and protein expressions of type I collagen and matrix metalloproteinase 2 via JAK1\/2\u2010STAT3 signalling pathway. In addition, CXCR2 might inhibit cell migration via FAK\/MLC<jats:sub>2<\/jats:sub> pathway. Taken together, CXCR2 regulated protein production and affected cell behaviours of ppHSFs. It might be a potential therapeutic target for the hypertensive scleral remodelling.<\/jats:p>","DOI":"10.1111\/jcmm.17609","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T06:43:48Z","timestamp":1667976228000},"page":"5858-5871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["CXC\u2010 receptor 2 promotes extracellular matrix production and attenuates migration in peripapillary human scleral fibroblasts under mechanical strain"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2880-3839","authenticated-orcid":false,"given":"Chen","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Vision Science, Eye and Ear, Nose, Throat Hospital, Shanghai Medical College Fudan University  Shanghai China"},{"name":"NHC Key Laboratory of Myopia Fudan University  Shanghai China"},{"name":"Laboratory of Myopia Chinese 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