{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:30:53Z","timestamp":1787884253034,"version":"build-2784847793"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010564","name":"Academic Medical Organization of Southwestern Ontario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Coronavirus disease 2019 (COVID\u201019) is a systemic inflammatory condition with high mortality that may benefit from personalized medicine and high\u2010precision approaches. COVID\u201019 patient plasma was analysed with targeted proteomics of 1161 proteins. Patients were monitored from Days 1 to 10 of their intensive care unit (ICU) stay. Age\u2010 and gender\u2010matched COVID\u201019\u2010negative sepsis ICU patients and healthy subjects were examined as controls. Proteomic data were resolved using both cell\u2010specific annotation and deep\u2010analysis for functional enrichment. COVID\u201019 caused extensive remodelling of the plasma microenvironment associated with a relative immunosuppressive milieu between ICU Days 3\u20137, and characterized by extensive organ damage. COVID\u201019 resulted in (1) reduced antigen presentation and B\/T\u2010cell function, (2) increased repurposed neutrophils and M1\u2010type macrophages, (3) relatively immature or disrupted endothelia and fibroblasts with a defined secretome, and (4) reactive myeloid lines. Extracellular matrix changes identified in COVID\u201019 plasma could represent impaired immune cell homing and programmed cell death. The major functional modules disrupted in COVID\u201019 were exaggerated in patients with fatal outcome. Taken together, these findings provide systems\u2010level insight into the mechanisms of COVID\u201019 inflammation and identify potential prognostic biomarkers. Therapeutic strategies could be tailored to the immune response of severely ill patients.<\/jats:p>","DOI":"10.1111\/jcmm.17622","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T02:52:37Z","timestamp":1671504757000},"page":"141-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["COVID\u201019 plasma proteome reveals novel temporal and cell\u2010specific signatures for disease severity and high\u2010precision disease management"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0535-8605","authenticated-orcid":false,"given":"Cristiana","family":"Iosef","sequence":"first","affiliation":[{"name":"Children's Health research Institute  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio M.","family":"Martin","sequence":"additional","affiliation":[{"name":"Lawson Health Research Institute  London Ontario Canada"},{"name":"Department of Medicine Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marat","family":"Slessarev","sequence":"additional","affiliation":[{"name":"Lawson Health Research Institute  London Ontario Canada"},{"name":"Department of Medicine Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Gillio\u2010Meina","sequence":"additional","affiliation":[{"name":"Children's Health research Institute  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gediminas","family":"Cepinskas","sequence":"additional","affiliation":[{"name":"Lawson Health Research Institute  London Ontario Canada"},{"name":"Department of Medical Biophysics Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor K. 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