{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:31:51Z","timestamp":1792690311452,"version":"4.5.0"},"reference-count":155,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Centella asiatica<\/jats:italic>\n                    is an ethnomedicinal herbaceous species that grows abundantly in tropical and sub\u2010tropical regions of China, India, South\u2010Eastern Asia and Africa. It is a popular nutraceutical that is employed in various forms of clinical and cosmetic treatments.\n                    <jats:italic>C. asiatica<\/jats:italic>\n                    extracts are reported widely in Ayurvedic and Chinese traditional medicine to boost memory, prevent cognitive deficits and improve brain functions. The major bioactive constituents of\n                    <jats:italic>C. asiatica<\/jats:italic>\n                    are the pentacyclic triterpenoid glycosides, asiaticoside and madecassoside, and their corresponding aglycones, asiatic acid and madecassic acid. Asiaticoside and madecassoside have been identified as the marker compounds of\n                    <jats:italic>C. asiatica<\/jats:italic>\n                    in the Chinese Pharmacopoeia and these triterpene compounds offer a wide range of pharmacological properties, including neuroprotective, cardioprotective, hepatoprotective, wound healing, anti\u2010inflammatory, anti\u2010oxidant, anti\u2010allergic, anti\u2010depressant, anxiolytic, antifibrotic, antibacterial, anti\u2010arthritic, anti\u2010tumour and immunomodulatory activities. Asiaticoside and madecassoside are also used extensively in treating skin abnormalities, burn injuries, ischaemia, ulcers, asthma, lupus, psoriasis and scleroderma. Besides medicinal applications, these phytocompounds are considered cosmetically beneficial for their role in anti\u2010ageing, skin hydration, collagen synthesis, UV protection and curing scars. Existing reports and experimental studies on these compounds between 2005 and 2022 have been selectively reviewed in this article to provide a comprehensive overview of the numerous therapeutic advantages of asiaticoside and madecassoside and their potential roles in the medical future.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.17635","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T03:08:05Z","timestamp":1675912085000},"page":"593-608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":218,"title":["Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review"],"prefix":"10.1111","volume":"27","author":[{"given":"Shinjini","family":"Bandopadhyay","sequence":"first","affiliation":[{"name":"Amity Institute of Biotechnology Amity University  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Presidency University  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimosa","family":"Ghorai","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Presidency University  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9486-4069","authenticated-orcid":false,"given":"Niraj Kumar","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Engineering &amp; Technology Sharda University  Greater Noida India"},{"name":"Department of Biotechnology Engineering and Food Technology Chandigarh University  Mohali India"},{"name":"Department of Biotechnology, School of Applied &amp; Life Sciences (SALS) Uttaranchal University  Dehradun India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Chemical and Biochemical Processing Division ICAR \u2013 Central Institute for Research on Cotton Technology  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Radha","sequence":"additional","affiliation":[{"name":"School of Biological and Environmental Sciences Shoolini University of Biotechnology and Management Sciences  Solan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arabinda","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Botany Gauhati University  Guwahati India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4100-3438","authenticated-orcid":false,"given":"Jaros\u0142aw","family":"Pro\u0107k\u00f3w","sequence":"additional","affiliation":[{"name":"Department of Plant Biology, Institute of Environmental Biology Wroc\u0142aw University of Environmental and Life Sciences  Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4663-5565","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"P\u00e9rez de la Lastra","sequence":"additional","affiliation":[{"name":"Instituto de Productos Naturales y Agrobiolog\u00eda (IPNA) Consejo Superior de Investigaciones cient\u00edficas (CSIS)  Santa Cruz de Tenerife Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5750-0802","authenticated-orcid":false,"given":"Abhijit","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Presidency University  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-017-9528-y"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0944-7113(00)80065-3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules14103922"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1556\/JPC.24.2011.1.16"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16021310"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.05.156"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00112"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.568032"},{"key":"e_1_2_11_10_1","first-page":"81","article-title":"Pharmacology of medicinal plants and natural products","volume":"32","author":"Dahanukar S","year":"2000","journal-title":"Indian J Pharmacol"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113930"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.78519"},{"issue":"4","key":"e_1_2_11_13_1","first-page":"348","article-title":"Andrographis paniculata (Burm. f.) wall. 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