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Recently, in the model of DSS (Dextran Sulfate Sodium Salt) \u2010induced intestinal inflammatory injury, it has been found in the study that transgenic mice expressing hVDR in IEC (Intestinal Epithelial Cell) manifest highly anti\u2010injury properties in colitis, suggesting that activated VDR in the epithelial cells of intestine may inhibit colitis by protecting the mucosal epithelial barrier. In this study, we investigated the effect of the expression and regulation of VDR on the protection of RIII, and the radiosensitivity in vitro experiments, and explored the initial mechanism of VDR in regulating radiosensitivity of IEC. As a result, we found that the expression of VDR in intestinal tissues and cells in mice can be induced by ionizing radiation. VDR agonists are able to prolong the average survival time of mice after radiation and reduce the radiation\u2010induced intestinal injury. For lack of vitamin D, the radiosensitivity of intestinal epithelial cells in mice increased, which can be reduced by VDR activation. Ensuing VDR activation, the radiation\u2010induced intestinal stem cells damage is decreased, and the regeneration and differentiation of intestinal stem cells is promoted as well. Finally, on the basis of sequencing analysis, we validated and found that VDR may target the HIF\/PDK1 pathway to mitigate RIII. We concluded that agonism or upregulation of VDR expression attenuates radiation\u2010induced intestinal damage in mice and promotes the repair of epithelial damage in intestinal stem cells.<\/jats:p>","DOI":"10.1111\/jcmm.17645","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T08:24:17Z","timestamp":1672302257000},"page":"246-258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Protective effects of activated vitamin D receptor on <scp>radiation\u2010induced<\/scp> intestinal injury"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6309-1796","authenticated-orcid":false,"given":"Yuhan","family":"Lin","sequence":"first","affiliation":[{"name":"School of Public Health and Management Wenzhou Medical University  Zhejiang 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