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However, the roles of FST and activin A in migration of decidualized endometrial stromal cells are not well characterized. In this study, transwell chambers and microfluidic devices were used to assess the effects of FST and activin A on migration of decidualized mouse endometrial stromal cells (d\u2010MESCs). We found that compared with activin A, FST exerted more significant effects on adhesion, wound healing and migration of d\u2010MESCs. Similar results were also seen in the primary cultured decidual stromal cells (DSCs) from uterus of pregnant mouse. Simultaneously, the results revealed that FST increased calcium influx and upregulated the expression levels of the migration\u2010related proteins MMP9 and Ezrin in d\u2010MESCs. In addition, FST increased the level of phosphorylation of JNK in d\u2010MESCs, and JNK inhibitor AS601245 significantly attenuated FST action on inducing migration of d\u2010MESCs. These data suggest that FST, not activin A in activin A\u2010FST system, is a crucial chemoattractant for migration of d\u2010MESCs by JNK signalling to facilitate the successful uterine decidualization and tissue remodelling during pregnancy.<\/jats:p>","DOI":"10.1111\/jcmm.17648","type":"journal-article","created":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T13:31:10Z","timestamp":1671370270000},"page":"127-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Follistatin is a crucial chemoattractant for mouse decidualized endometrial stromal cell migration by\n                    <scp>JNK<\/scp>\n                    signalling"],"prefix":"10.1111","volume":"27","author":[{"given":"Guole","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Immunology, College of Basic Medical Sciences Jilin University  Changchun 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