{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T18:55:57Z","timestamp":1788029757077,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20211324"],"award-info":[{"award-number":["BK20211324"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Cellular Molecular Medi"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mitochondria are cellular organelles that are involved in various metabolic processes, and damage to mitochondria can affect cell health and even lead to disease. Mitophagy is a mechanism by which cells selectively wrap and degrade damaged mitochondria to maintain cell homeostasis. However, studies have not focused on whether mitophagy is involved in the occurrence of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    )\u2010induced mastitis in dairy cows. Here, we found that\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    infection of bovine macrophages leads to oxidative damage and mitochondria damage. The expression of LC3, PINK1 and Parkin was significantly increased after intracellular infection. We observed changes in the morphology of mitochondria and the emergence of mitochondrial autolysosomes in bovine macrophages by transmission electron microscopy and found that enhanced mitophagy promoted bacterial proliferation in the cell. In conclusion, this study demonstrates that\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    infection of bovine macrophages induces mitophagy through the PINK1\/Parkin pathway, and this mechanism is used by the bacteria to avoid macrophage\u2010induced death. These findings provide new ideas and references for the prevention and treatment of\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1111\/jcmm.17664","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T02:47:04Z","timestamp":1673318824000},"page":"412-421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["PINK1\/Parkin\u2010mediated mitophagy enhances the survival of\n                    <i>Staphylococcus aureus<\/i>\n                    in bovine macrophages"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-2932","authenticated-orcid":false,"given":"Xi","family":"Zhou","sequence":"first","affiliation":[{"name":"Jiangsu Co\u2010innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary 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