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Quercetin, a bioflavonoid, has shown potent anti\u2010inflammatory effects. However, its effect on preventing OA progression and the underlying mechanisms are still unclear. In this study, Sprague\u2013Dawley male rats were divided into five groups: control group, OA group (monosodium iodoacetate intra\u2010articular injection), and three quercetin\u2010treated groups. Quercetin\u2010treated groups were treated with intragastric quercetin once a day for 28\u2009days. Gross observation and histopathological analysis showed cartilage degradation and matrix loss in the OA group. High\u2010dose quercetin\u2010group joints showed failure in OA progression. High\u2010dose quercetin inhibited the OA\u2010induced expression of MMP\u20103, MMP\u201013, ADAMTS4, and ADAMTS5 and promoted the OA\u2010reduced expression of aggrecan and collagen II. Levels of most inflammatory cytokines and growth factors tested in synovial fluid and serum were upregulated in the OA group and these increases were reversed by high\u2010dose quercetin. Similarly, subchondral trabecular bone was degraded in the OA group and this effect was reversed in the high\u2010dose quercetin group. Our findings indicate that quercetin has a protective effect against OA development and progression possibly via maintaining the inflammatory cascade homeostasis. Therefore, quercetin could be a potential therapeutic agent to prevent OA progression in risk groups.<\/jats:p>","DOI":"10.1111\/jcmm.17672","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T10:10:43Z","timestamp":1675246243000},"page":"515-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Quercetin prevents osteoarthritis progression possibly via regulation of local and systemic inflammatory cascades"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7009-133X","authenticated-orcid":false,"given":"Haiyan","family":"Wang","sequence":"first","affiliation":[{"name":"Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine  Guangzhou China"},{"name":"Laboratory for Myology, 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